Leaders: Maud Borensztein & Bénédicte Delaval
The Development & Tissue Dynamics Axis brings together 12 teams addressing fundamental questions related to the development of living organisms under normal and pathological conditions. The teams explore the mechanisms that drive embryonic development, and tissue organization, maintenance and repair across different biological scales.
This multidisciplinary axis integrates expertise in Developmental Biology, Cell Biology, Biophysics and Bioinformatics, applied to a wide range of models, from 2D/3D cell culture, gastruloids and organoids to invertebrate and vertebrate in vivo systems.
Using these advanced models, alongside cutting-edge live imaging tools, genomics, computational modelling and biophysics, the teams aim to elucidate:
- how stem cells acquire and maintain their identify,
- how cells coordinate to form functional tissues, organs and organisms,
- and how the interplay between genetic regulation and physical forces influences tissue morphogenesis.
By fostering collaboration across disciplines, the teams strive for a better understanding of developmental mechanisms, while advancing regenerative medicine, tissue engineering, and understanding of the origin of diseases.
Teams involved: Jean-Christophe Andrau, Maud Borensztein, Laura Boulan, Julie Carnesecchi, Anne Debant, Bénédicte Delaval, François Fagotto, Robert Feil, Dan Fisher, Mounia Lagha, Frédéric Landmann, Patrick Lemaire & Albert Tsai