Leaders: Caroline Goujon & Nadine Laguette
Second Symposium on 2026, February the 5th: Register here
The BIOLuM Infection and Immunity Axis unites a dynamic consortium of research teams from IRIM and IGMM, whose collective work explores the intricate dialogue between infectious agents and host cellular mechanisms. At the core of their investigations lie fundamental questions related to virus-host interactions, innate immune responses, cellular stress pathways, metabolism and the preservation of genome integrity in the face of internal and external threats.
This axis fosters interdisciplinary collaboration across molecular, cellular, and systems biology to address current and emerging infectious challenges. Researchers apply a wide array of state-of-the-art technologies, including functional genomics (e.g., genome-wide CRISPR-based screens), high-resolution and live-cell microscopy, proteomics, transcriptomics, metabolomics, and single-cell approaches. Advanced tools in molecular virology and cell biology are extensively employed to dissect both pathogen behavior and host defenses.
Despite their thematic diversity, the teams share a unifying goal: to understand how infections, immune pressure, and cellular stress influence host cell function and determine cell fate. Their research not only advances fundamental biological knowledge but also informs the development of innovative antiviral or antibacterial strategies and deepens our understanding of how infections contribute to chronic inflammation, immune dysfunction, or cancer development.
Teams involved: Nathalie Arhel & Sébastien Nisole, Bruno Beaumelle, Matteo Bonazzi, Guillaume Bossis, Laurence Briant & Jean-Luc Battini, Lucile Espert & Mickael Blaise, Raphael Gaudin, Caroline Goujon, Mickael Hahne, Eric Kremer, Laurent Kremer, Nadine Laguette, Frédéric Landmann, Karim Majzoub, Delphine Muriaux & Cyril Favard, Laura Picas, Valérie Zimmermann.