Leaders: Isabelle Vila, Dimitris Xirodimas & Alenka Copič
Inaugural symposium was held on 2025, November 19th
The Metabolism-Proteostasis axis explores the dynamic interface between cellular metabolism and protein homeostasis, focusing on how processes like lipid metabolism, fatty acid signaling, and mitochondrial energetics coordinate with protein turnover and quality control mechanisms. It investigates lipid droplet biology, lipolysis, and energy production pathways—including mitochondrial function, glucose sensing, and redox homeostasis—as key contributors to cellular metabolism and proteostasis.
This axis also examines the role of organelle crosstalk via membrane contact sites, autophagy pathways, and metabolite interconversion, including how these processes impact on nuclear organization and epigenetic states. Condensate formation, protein/RNA aggregates, and post-translational modifications are analyzed as critical nodes linking metabolic states to proteostasis.
Additionally, the axis assesses how these processes, as well as environmental stress impact on cell and tissue growth. Disease relevance spans metabolic reprogramming in cancer, obesity, and neurodegenerative disorders, offering insights into how metabolic dysregulation drives proteostasis failure, ultimately enabling the development of targeted, precision medicine strategies.
Teams involved: Guillaume Bossis, Laurence Briant & Jean-Luc Battini, Fabrice Caudron, Alenka Copic, Lucile Espert & Mickael Blaise, Mickael Hahne, Nadine Laguette, Dimitris Liakopoulos, Domenico Libri & Odil Porrua, Maria Moriel-Carretero, Laura Picas, Dimitris Xirodimas, Valérie Zimmermann.