Leaders: Simonetta Piatti & Mickael Hahne
First Symposium on 2026, June 3rd, register here
The Cell Cycle and Cancer Axis brings together 13 multidisciplinary teams to investigate key aspects of cancer biology, with a particular focus on cell cycle regulation.
The research integrates a variety of model organisms – including mouse, Drosophila, Xenopus, C. elegans, zebrafish and yeast – as well as advanced 2D and 3D cell culture systems and patient-derived biopsies.
Using a broad range of state-of-the-art approaches, the teams address questions such as:
- how epigenetic and posttranslational changes contribute to cancer development,
- what are the molecular processes that govern cell division under physiological and pathological conditions,
- how signaling pathways are rewired in cancer cells,
- and how inflammatory, metabolic, and other cues from the tumor microenvironment affect disease progression.
Through a collaborative framework, this axis aims to strengthen the connections between basic research and clinical relevance, contributing to a more comprehensive understanding of how cancer cells proliferate, with the final purpose to discover potential avenues for future therapies.
Teams involved: Guillaume Bossis, Anna Castro & Thierry Lorca, Bénédicte Delaval, Daniel Fisher, Michael Hahne, Nadine Laguette, Dimitris Liakopoulos, Domenico Libri & Odil Porrua, Simonetta Piatti, Serge Roche, Étienne Schwob, Éric Soler, Valérie Zimmermann
